P0547

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P0547

Sigma

 

Pentamidine isethionate salt

powder

Synonym:4,4′-(Pentamethylenedioxy)dibenzamidine bis(2-hydroxyethanesulfonate), 1,5-Bis(p-amidinophenoxy)pentane bis(2-hydroxyethanesulfonate salt)
CAS Number:140-64-7
Linear Formula:CH2[CH2CH2OC6H4C(=NH)NH2]2·2HOCH2CH2SO3H
Molecular Weight:592.68
EC Number:205-424-1
MDL number:MFCD00079213
PubChem Substance ID:24277999

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Description

ApplicationAntimicrobial against Pneumocystis carinii.
Biochem/physiol ActionsNeuroprotective; inhibits constitutive nitric oxide synthase in the brain; NMDA glutamate receptor antagonist.

Properties

formpowder
mp188-194 °C(lit.)
Gene Informationhuman ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907), NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
storage temp.−20°C

Safety

Hazard CodesXi
Risk Statements36/37/38-43
Safety Statements26-36/37
WGK Germany3
RTECSCV6500000

References

referenceReynolds, et al., Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. J. Neurosci. 12, 970, (1992) Abstract
MerckMerck 13,7192